Perioperative medicine & outcomes
Effect of Intraoperative Midazolam on Postoperative Delirium in Older Surgical Patients: A Prospective, Multicenter Cohort Study
Authors' conclusion
Intraoperative administration of midazolam may not be associated with an increased risk of postoperative delirium in older patients undergoing noncardiac surgery.
Study context
- Population
- Patients aged 65 yr and older undergoing noncardiac surgery under GA, multiple hospitals in China, April 2020–April 2022
- Participants
- 5,663 patients
- Exposure
- Intraoperative midazolam vs no midazolam
- Outcome
- Postoperative delirium (3-min Diagnostic Interview for Confusion Assessment Method)
- Follow-up
- Within 7 days
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
Midazolam vs No midazolamEstimate (95% CI)P value
Midazolam
unadjusted RR 0.96(0.90–1.30)
P = 0.38Random effects of hospitals
adjusted RR 1.09(0.91–1.33)
P = 0.35- Postoperative delirium overall incidence
- 723 (12.8%)
Observational data: associations, not effects.
Further findings
Time to postoperative delirium onset (Kaplan-Meier)
- No difference in distribution of time to postoperative delirium onset
Postoperative delirium, specific subgroups (subgroup)
- Intraoperative midazolam not associated with postoperative delirium in the specific subgroups
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Effect of Intraoperative Midazolam on Postoperative Delirium in Older Surgical Patients: A Prospective, Multicenter Cohort Study. Anesthesiology. Published 29 October 2024. doi:10.
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