Pediatric anesthesia & critical care
Effect of Low-dose Ketamine Infusion on Opioid Consumption in Children Undergoing Open Cardiac Surgery: A Randomized Controlled Double-Blind Study
Authors' conclusion
Low-dose ketamine infusion in children undergoing open cardiac surgery reduced intra- and postoperative opioid consumption and postoperative pain scores.
Study context
- Population
- Children aged 2–12 years undergoing open cardiac surgery, tertiary care children's hospitalrecruited
- Participants
- 80 children
- Comparison
- Low-dose ketamine infusion vs normal saline
- Ketaminen = 35
- Controln = 34reference
- Primary endpoint
- Total fentanyl dose consumed
- Follow-up
- First 24 hours postoperatively
Methodological detailsdouble-blinded, single-centre
- Double-blinded
- Single-centre
Primary result
As reported in the abstract
Fentanyl consumption
- Significantly lower in the ketamine than the control group
Secondary outcomes
Intraoperative fentanyl consumption
- Significantly lower in the ketamine than the control group
Time to extubation
- Similar in both groups
Modified objective pain score
- Significantly lower in the ketamine group than the control group
Safety
Events
| Outcome | Ketamine | Control |
|---|---|---|
| Diplopia or hallucinations | 0 | 0 |
Original publication
Effect of Low-dose Ketamine Infusion on Opioid Consumption in Children Undergoing Open Cardiac Surgery: A Randomized Controlled Double-Blind Study. J Cardiothorac Vasc Anesth. Published 25 April 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →