Effect of real-time binaural music on sedation with dexmedetomidine during spinal anesthesia: A triple-arm, assessor-blind, randomized controlled trial
Authors' conclusion
Compared with no music, music with binaural sound reduced the dexmedetomidine loading dose; however, this sedative-sparing effect of binaural sound was not found when compared to plain music.
Study context
- Population
- Patients undergoing orthopedic surgery under spinal anesthesia with dexmedetomidine sedation184 analysed
- Participants
- 189 patients
- Comparison
- Binaural vs Plain music vs Control
- Primary endpoint
- Dexmedetomidine loading dose adjusted for predicted body weight (PBW) (binaural vs plain music; binaural vs control)
Methodological detailstriple-arm, assessor-blind
- Triple-arm
- Assessor-blind
Primary result
As reported in the abstract
PBW-adjusted dexmedetomidine loading dose
Mean difference, μg/kg PBW (95% CI)P value
Binaural vs Control
0.18(0.06–0.29)
P = 0.002Binaural vs Plain music
0.11(−0.01 to 0.23)
P = 0.070Secondary outcomes
Dexmedetomidine total dose, recovery from sedation, patient satisfaction score
- No difference among the three groups
Original publication
Effect of real-time binaural music on sedation with dexmedetomidine during spinal anesthesia: A triple-arm, assessor-blind, randomized controlled trial. J Clin Anesth. Published 10 November 2022. doi:10.
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