Cardiothoracic & vascular anesthesia
Effect of Retrograde Autologous Priming on Coagulation Assessed by Rotation Thromboelastometry in Patients Undergoing Valvular Cardiac Surgery
Authors' conclusion
Cardiopulmonary bypass induced impaired coagulation function on ROTEM. However, RAP did not improve coagulation function when compared with conventional priming in patients undergoing valvular cardiac surgery.
Study context
- Population
- Patients aged 20 years or older undergoing valvular cardiac surgery1:1 allocation
- Participants
- 104 patients
- Comparison
- Retrograde autologous priming vs conventional priming
Methodological detailsprospective, patient- and outcome assessor-blinded, single-centre, Allogeneic plasma products and platelet concentrates transfused according to rotation thromboelastometry (ROTEM)-based algorithms
- Prospective
- Patient- and outcome assessor-blinded
- Single-centre
- Allogeneic plasma products and platelet concentrates transfused according to ROTEM-based algorithms
Primary result
As reported in the abstract
ROTEM clotting time and maximal clot firmness · after CPB
- Prolonged clotting time and decreased maximal clot firmness after cardiopulmonary bypass (CPB) in both groups without intergroup differences
Further findings
Hematocrit · 10 minutes after CPB
P = 0.330
Intraoperative erythrocyte transfusion
P = 0.823
FFP transfusion
P = 0.339
Cryoprecipitate transfusion
P = 0.185
Platelet concentrate transfusion
P = 0.277
- Volume removed by retrograde autologous priming (RAP) (from 1,600 mL initial prime)
- 635 · mean · SD 114 · mL
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Effect of Retrograde Autologous Priming on Coagulation Assessed by Rotation Thromboelastometry in Patients Undergoing Valvular Cardiac Surgery. J Cardiothorac Vasc Anesth. Published 29 December 2023. doi:10.
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