Effect of postoperative intermittent boluses of subcostal quadratus lumborum block on pulmonary function recovery and analgesia after gastrectomy: a randomized controlled clinical trial
Authors' conclusion
Postoperative intermittent boluses of subcostal QLB did not confer advantages in terms of the preservation of FEV1 or pain scores on coughing 24 h after gastrectomy. However, notable effects were observed in analgesia at rest and FVC recovery.
Study context
- Population
- Patients scheduled for gastrectomy59 analysed (modified ITT)
- Participants
- 60 patients
- Comparison
- Intervention vs Control
- Primary endpoint
- Two primary outcomes: preservation of FEV1 and pain scores (0-10 cm VAS) on coughing
- Follow-up
- 24 h postoperatively
Primary result
As reported in the abstract
- Preservation of FEV1 did not differ significantly between the two groups: median difference 4.0%, 97.5% CI −5.7 to 14.9
- P = 0.332
- Pain scores on coughing did not differ significantly between the two groups: mean difference 0.0 cm, 97.5% CI −1.1 to 1.2
- P = 0.924
Secondary outcomes
| Outcome | Median difference (mg) (95% CI) | P value | |
|---|---|---|---|
| IV morphine consumptionIntervention vs Control · 0-24 h | −3 (−6 to −1) | P = 0.014 | |
| IV morphine consumptionIntervention vs Control · total 72 h | −5 (−10 to −1) | P = 0.019 | |
| −15−10−505Difference, mg (linear scale) |
| Outcome | Median difference (95% CI) | P value | |
|---|---|---|---|
| Number of rescue analgesia · 24-48 h | 0 (0–0) | P = 0.043 | |
| 0000000Difference (linear scale) |
| Outcome | Estimate | P value |
|---|---|---|
| FVC recovery (interaction group*(Day3-Day0)) · up to 72 hSE =0.13 | estimated effect (β) 0.30 L | P = 0.025 |
| Pain scores at rest · Day1–Day3Intervention vs Control · SE = 0.4 | β (Day1-Day0) - 0.8 cm | P = 0.035 |
| Pain scores at rest · Day1–Day3Intervention vs Control · SE = 0.4 | β (Day2-Day0) - 1.0 cm | P = 0.014 |
| Pain scores at rest · Day1–Day3Intervention vs Control · SE = 0.4 | β (Day3-Day0) - 1.0 cm | P = 0.009 |
Other outcomes
- No statistical differences
Original publication
Effect of postoperative intermittent boluses of subcostal quadratus lumborum block on pulmonary function recovery and analgesia after gastrectomy: a randomized controlled clinical trial. J Clin Anesth. Published 5 April 2024. doi:10.
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