The Effect of Remimazolam Administration on Emergence Delirium in Children After General Anesthesia: A Systematic Review With Meta‐Analysis of Randomized Controlled Trials
Pooled resultResult — go to the resultRelative risk 0.38 95% CI 0.23–0.63Authors' conclusion
Remimazolam may reduce the incidence and severity of emergence delirium in children after general anesthesia, without affecting hemodynamic stability or recovery time.
Study context
- Population
- Children undergoing GA
- Participants
- 1,231 children · 10 RCTs
- Comparison
- Remimazolam vs control
- Outcome
- Incidence of emergence delirium
Methodological detailsrandom-effects model
- Random-effects model
Pooled result
As reported in the abstract
Relative risk
0.38
95% CI 0.23–0.63
P = 0.0002
Remimazolam vs Control
RR 0.38 (95% CI 0.23–0.63); P = 0.0002
Further pooled results
| Outcome | MD (95% CI) | P value | |
|---|---|---|---|
| Pediatric Anesthesia Emergence Delirium score | −1.70 (−2.77 to −0.63) | P = 0.0019 | |
| −4−202Difference (linear scale) |
| Outcome | MD | P value |
|---|---|---|
| Extubation time, overall | −0.75 | P = 0.5088 |
| Extubation time, propofol comparator (subgroup)Remimazolam vs Propofol | −3.36 | P < 0.0001 |
PACU stay and PONV
- No significant differences
Safety
| Outcome | RR | P value |
|---|---|---|
| HypotensionRemimazolam vs Control · overall; no significant difference · subgroup analysis | 0.35 | P = 0.0991 |
| HypotensionRemimazolam vs Propofol · subgroup analysis vs propofol · subgroup analysis | 0.14 | P = 0.0376 |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
The Effect of Remimazolam Administration on Emergence Delirium in Children After General Anesthesia: A Systematic Review With Meta‐Analysis of Randomized Controlled Trials. Paediatr Anaesth. Published 5 March 2026. doi:10.
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