Neuroanesthesia & neurocritical care
Effect of remimazolam versus propofol anesthesia on postoperative delirium in neurovascular surgery: study protocol for a randomized controlled, non-inferiority trial
Study context
- Population
- Adults, ASA I–III, undergoing elective neurovascular surgery under GAplanned
- Participants
- 696 adults
- Planned comparison
- Remimazolam- vs propofol-based total intravenous anesthesia (TIVA)
- Primary endpoint
- Incidence of POD
- Follow-up
- Within 5 days after surgery
Methodological detailsdouble-blind, non-inferiority, 1:1 randomisation, modified ITT analysis, Secondary outcomes: Postoperative delirium (POD) subtypes, number of positive assessments and severity, emergence agitation, intraoperative awareness and undesirable movement, intraoperative hypotension, postoperative cognitive function
- Double-blind
- Non-inferiority
- 1:1 randomisation
- Modified ITT analysis
- Secondary outcomes: POD subtypes, number of positive assessments and severity, emergence agitation, intraoperative awareness and undesirable movement, intraoperative hypotension, postoperative cognitive function
No results yet. This paper sets out the design of a trial; its results are to come.
Original publication
Effect of remimazolam versus propofol anesthesia on postoperative delirium in neurovascular surgery: study protocol for a randomized controlled, non-inferiority trial. Perioper Med (Lond). Published 14 June 2024. doi:10.
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