Effects of ciprofol on respiratory-related adverse incidence in patients with obesity during painless gastroscopy: a prospective, randomized clinical trial
Authors' conclusion
0.4 mg/kg of ciprofol provides anesthesia comparable with 2.0 mg/kg of propofol. However, it is related to reduced respiratory-related AEs and hypotension during gastroscopy in patients with obesity
Study context
- Population
- Patients with obesity scheduled for gastroscopy
- Participants
- 84 patients
- Comparison
- Ciprofol vs propofol sedation for painless gastroscopy
- Primary endpoint
- Incidence of respiratory-related AEs
Methodological detailsprospective
- Prospective
Primary result
As reported in the abstract
Respiratory-related AEs
P < 0.001
Secondary outcomes
| Outcome | P value |
|---|---|
| Movement during procedureMarkedly reduced in C | P = 0.007 |
Procedure and anesthesia success rates
- No notable differences between groups (P > 0.05)
Patient, anesthesiologist and endoscopist satisfaction
- Comparable between groups (P > 0.05)
Safety
| Outcome | P value |
|---|---|
| HypotensionMarkedly reduced in C | P = 0.024 |
Additional adverse events (AEs)
- No notable differences between groups (P > 0.05)
Original publication
Effects of ciprofol on respiratory-related adverse incidence in patients with obesity during painless gastroscopy: a prospective, randomized clinical trial. Perioper Med (Lond). Published 29 April 2025. doi:10.
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