Effect of intravenous lidocaine on the effective dose (ED50) of propofol induction dose in elderly patients undergoing painless gastroscopy: a prospective, randomized, double-blinded, controlled study
Authors' conclusion
The administration of intravenous lidocaine to elderly patients undergoing painless gastroscopy resulted in a significant 40% reduction in the ED50 of propofol induction dose, which may be related to the decreased incidence of hypotension and injection pain, as well as the improved post-gastroscopy orientation recovery.
Study context
- Population
- Patients aged ≥ 60 years undergoing painless gastroscopy64 randomised
- Participants
- 70 patients
- Comparison
- L vs N
- Ln = 31
- Nn = 33reference
- Primary endpoint
- ED50 of the propofol induction dose
Methodological detailsprospective, double-blinded, Dixon up-and-down sequential method
- Prospective
- Double-blinded
- Dixon up-and-down sequential method
Primary result
As reported in the abstract
ED50 of propofol induction dose
P < 0.001
Further findings
| Outcome | P value |
|---|---|
| Orientation recovery timeShorter in group L | P < 0.05 |
Safety
| Outcome | L | P value |
|---|---|---|
| Hypotension and propofol injection painLower incidence in group L | P < 0.05 | |
| Local anaesthetic intoxication reactions | 0 events |
Original publication
Effect of intravenous lidocaine on the ED50 of propofol induction dose in elderly patients undergoing painless gastroscopy: a prospective, randomized, double-blinded, controlled study. Perioper Med (Lond). Published 5 March 2024. doi:10.
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