Pediatric anesthesia & critical care
Effects of dexamethasone on opioid consumption in pediatric tonsillectomy: a systematic review with meta-analysis
Pooled resultResult — go to the resultMD −0.11 mg·kg-1 oral morphine equivalent 95% CI −0.22 to −0.01Authors' conclusion
Intravenous dexamethasone reduced perioperative opioid consumption in pediatric tonsillectomy without increasing the incidence of postoperative hemorrhage.
Study context
- Population
- Children undergoing tonsillectomy16 RCTs
- Comparison
- IV dexamethasone vs placebo
- Outcome
- Perioperative opioid consumption
Methodological detailsrandom effects meta-analysis
- Random effects meta-analysis
Pooled result
As reported in the abstract
MD
−0.11 mg·kg-1 oral morphine equivalent
95% CI −0.22 to −0.01
Dexamethasone vs Placebo
MD −0.11 mg·kg-1 oral morphine equivalent (95% CI −0.22 to −0.01)
Safety
| Outcome | RR (95% CI) | |
|---|---|---|
| Readmission | 0.69 (0.28–1.67) | |
| Reoperation due to postoperative hemorrhage | 3.67 (0.79–17.1) | |
| 0.050.21520Relative risk (log scale) |
Original publication
Effects of dexamethasone on opioid consumption in pediatric tonsillectomy: a systematic review with meta-analysis. Can J Anaesth. Published 27 August 2024. doi:10.
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