Hemodynamics, fluids & transfusion
Effects of ephedrine and phenylephrine on cerebral oxygenation: observational prospective study using near-infrared time-resolved spectroscopy
Authors' conclusion
The changes in ScO2 and tHb after treatments with ephedrine and phenylephrine were very small and clinically insignificant when measured by TRS.
Study context
- Population
- Patients during laparoscopic surgery
- Participants
- 50 treatments
- Exposure
- Changes in ScO2 and tHb after ephedrine or phenylephrine
- Outcome
- Changes in cerebral oxygenation (ScO2) and total cerebral hemoglobin concentration (tHb) measured by time-resolved spectroscopy (TRS)
Methodological detailstime-resolved spectroscopy, mixed-effects model
- Time-resolved spectroscopy
- Mixed-effects model
Main finding
As reported in the abstract
ScO2 and tHb changes
- Mean differences of ScO2 less than 0.1% for the two drugs
- Predicted mean differences of ScO2 less than 1.1%
- Mean differences of tHb less than 0.02 μM for the drugs
- Predicted mean differences of tHb less than 0.2 μM
- Mixed-effects model with random intercepts including mean BP; predicted differences using IQR of mean BP
Observational data: associations, not effects.
Original publication
Effects of ephedrine and phenylephrine on cerebral oxygenation: observational prospective study using near-infrared time-resolved spectroscopy. J Clin Monit Comput. Published 27 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →