Effects of intravenous lidocaine on propofol-based sedation in adult patients during gastrointestinal endoscopic procedures: an updated systematic review and meta-analysis
Pooled result · Propofol consumptionResult — go to the resultSMD −1.36 95 % CI −1.67 to −1.05Authors' conclusion
Intravenous lidocaine is a safe and effective adjunct to propofol sedation in gastrointestinal endoscopy, reducing anaesthetic requirements and sedation-related complications.
Study context
- Population
- Adults undergoing propofol sedation for gastrointestinal endoscopic procedures
- Participants
- 1,698 adults · 17 RCTs
- Comparison
- Intravenous (IV) lidocaine adjunct vs control during propofol sedation
- Outcome
- Propofol consumption
Methodological detailsupdated, Risk of bias assessed with RoB2, Search of PubMed/MEDLINE, Scopus and Web of Science, January to February 2025
- Updated
- Risk of bias assessed with RoB2
- Search of PubMed/MEDLINE, Scopus and Web of Science, January to February 2025
Pooled result
As reported in the abstract
SMD
−1.36
95 % CI −1.67 to −1.05
P < 0.001
IV lidocaine vs Control
SMD −1.36 (95 % CI −1.67 to −1.05); P < 0.001
Further pooled results
| Outcome | SMD (95 % CI) | P value | |
|---|---|---|---|
| Awakening time | −0.92 (−1.18 to −0.66) | P < 0.001 | |
| −1.5−1−0.500.5Difference (linear scale) |
Full recovery time
- No significant difference
Involuntary movements
- Reduction in involuntary movements with lidocaine
- 57 %
Lidocaine infusion regimen
- Continuous infusion after bolus required to achieve effects
- Infusion rates of 2 mg/kg/h and 4 mg/kg/h equally effective
Safety
%
- Reduction in desaturation events with lidocaine
- 59
- Reduction in hypotension events with lidocaine
- 36
Original publication
Effects of intravenous lidocaine on propofol-based sedation in adult patients during gastrointestinal endoscopic procedures: an updated systematic review and meta-analysis. J Clin Anesth. Published 9 August 2025. doi:10.
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