Effects of magnesium, phosphate, or zinc supplementation in intensive care unit patients—A systematic review and meta‐analysis
Authors' conclusion
In adult ICU patients, the certainty of evidence for the effects of supplementation with magnesium, phosphate, or zinc was very low.
Study context
- Population
- Adult intensive care unit (ICU) patientsno low risk of bias trials
- Comparison
- Magnesium, phosphate or zinc supplementation vs no supplementation/control
- Magnesiumn = 235
- Zincn = 168
- Outcome
- Mortality and duration of mechanical ventilation
Methodological detailsCochrane risk of bias 2, grading of recommendations, assessment, development and evaluation (GRADE)
- Cochrane risk of bias 2
- GRADE
Pooled result
As reported in the abstract
Mortality
Each group vs controlRelative risk (95% CI)
Magnesium3 trials (n = 235); very low certainty of evidence
0.54(0.30–0.96)
Zinc2 trials (n = 168)
0.73(0.41–1.28)
Further pooled results
Outcomes other than mortality
- Only zero or one trial available
Original publication
Effects of magnesium, phosphate, or zinc supplementation in intensive care unit patients—A systematic review and meta‐analysis. Acta Anaesthesiol Scand. Published 6 January 2023. doi:10.
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