Cardiothoracic & vascular anesthesia
Effects of naloxegol on transit recovery in patients undergoing cardiac surgery: A randomized, double-blind, placebo-controlled trial
Authors' conclusion
Naloxegol was not found to be effective in improving the transit time recovery after elective cardiac surgery.
Study context
- Population
- Patients over 18 years old undergoing non-urgent cardiac surgerymodified ITT analysis
- Participants
- 299 participants
- Comparison
- Naloxegol vs matching placebo
- Primary endpoint
- Time to postoperative gastrointestinal transit recovery (hours from anaesthetic induction to first significant stool)
Methodological detailssingle-centre, double-blind, placebo-controlled, phase 3
- Single-centre
- Double-blind
- Placebo-controlled
- Phase 3
Primary result
As reported in the abstract
P = 0.40
Secondary outcomes
Prespecified secondary efficacy endpoints
- No difference between groups
Safety
Pain levels and serious adverse events
- Not different in both groups
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Effects of naloxegol on transit recovery in patients undergoing cardiac surgery: A randomized, double-blind, placebo-controlled trial. Anaesth Crit Care Pain Med. Published 21 February 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →