Respiratory failure & ventilation
Effects of Oxygenation Targets on Mortality in Critically Ill Patients in Intensive Care Units: A Systematic Review and Meta-Analysis
Pooled result · Moderate certaintyResult — go to the resultRelative risk 1.00 95% CI 0.93–1.09Authors' conclusion
Critically ill ICU patients ≥18 years of age managed with lower and higher oxygenation targets did not differ in terms of mortality, RRT need, mechanical ventilation-free days through day 28, or ICU length of stay.
Study context
- Population
- Critically ill intensive care unit (ICU) patients ≥18 years undergoing mechanical ventilation, nasal cannula, oxygen mask or high-flow oxygen therapy
- Participants
- 7,416 patients · 12 randomized controlled trials (RCTs)
- Comparison
- Lower vs higher oxygenation targets
- Outcome
- Mortality
Methodological detailsrandom-effects model, Grading of Recommendations Assessment, Development and Evaluation (GRADE) certainty assessment
- Random-effects model
- GRADE certainty assessment
Pooled result
Moderate certainty
Relative risk
1.00
95% CI 0.93–1.09
Lower vs Higher
RR 1.00 (95% CI 0.93–1.09)
As reported in the abstract
Further pooled results
| Outcome | MD (95% CI) | |
|---|---|---|
| Mechanical ventilation-free days · day 28Low certainty | −0.05 (−1.23 to 1.13) | |
| ICU LOSVery low certainty | 1.05 (−0.04 to 2.13) | |
| −2−10123Difference (linear scale) |
| Outcome | RR (95% CI) | |
|---|---|---|
| RRTLow certainty | 0.96 (0.84–1.10) | |
| 0.512Relative risk (log scale) |
Safety
| Outcome | RR (95% CI) | |
|---|---|---|
| Serious adverse eventsHigh certainty | 0.93 (0.85–1.00) | |
| 0.512Relative risk (log scale) |
Original publication
Effects of Oxygenation Targets on Mortality in Critically Ill Patients in Intensive Care Units: A Systematic Review and Meta-Analysis. Anesth Analg. Published 4 September 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →