Hemodynamics, fluids & transfusion
Effects of phenylephrine on systemic and cerebral circulations in humans: a systematic review with mechanistic explanations
Study context
- Population
- Humans receiving phenylephrine (awake and anaesthetised)
- Outcome
- Phenylephrine-induced changes in BP, CO, cerebral blood flow and cerebral tissue oxygen saturation
Methodological detailsmechanistic explanations
- Mechanistic explanations
Pooled result
As reported in the abstract
- Correlation of CO change with BP change, awake
- r = −0.54, p = 0.09
- Correlation of CO change with BP change, anaesthetised
- r = −0.55, p = 0.007
- Correlation of cerebral blood flow change with BP change, awake
- r = 0.65, p = 0.002
- Correlation of cerebral blood flow change with BP change, anaesthetised
- r = 0.80, p = 0.003
- Correlation of cerebral tissue oxygen saturation change with BP change, awake
- r = −0.72, p = 0.03
- Correlation of cerebral tissue oxygen saturation change with BP change, anaesthetised
- r = −0.24, p = 0.48
Further pooled results
Awake vs anaesthetised
- No evidence of a significant difference in CO, cerebral blood flow or cerebral tissue oxygen saturation
Bolus vs infusion
- No evidence of a significant difference in effect on systemic and cerebral circulations
Original publication
Effects of phenylephrine on systemic and cerebral circulations in humans: a systematic review with mechanistic explanations. Anaesthesia. Published 10 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →