Efficacy of the intertransverse process block: single or multiple injection? A randomized, non-inferiority, blinded, cross-over trial in healthy volunteers
Primary resultResult — go to the resultMean difference 0.82 dermatomes 95% CI −0.41 to 2.05Authors' conclusion
Single-injection intertransverse process block is non-inferior to multiple injection in terms of anesthetized thoracic dermatomes.
Study context
- Population
- Healthy male volunteerscross-over
- Participants
- 12 volunteers
- Comparison
- Single-injection vs multiple-injection intertransverse process block
- Primary endpoint
- Number of anesthetized thoracic dermatomes (non-inferiority margin 1.5 dermatomes)
Methodological detailscross-over, non-inferiority, blinded
- Cross-over
- Non-inferiority
- Blinded
Primary result
As reported in the abstract
Mean difference
0.82 dermatomes
95% CI −0.41 to 2.05
pnon-inf<0.01
Single-injection vs Multiple-injection
mean difference 0.82 dermatomes (95% CI −0.41 to 2.05); pnon-inf<0.01
Non-inferiority margin 1.5 as printed, not drawn
Further findings
Cutaneous area, posterior hemithorax
- Significantly larger with multiple injection
Contralateral cutaneous involvement
- Both techniques, to a variable extent
MAP · 30 and 60 min postblock
- Decreased with multiple injection
Thoracic thermography
- No intermodality temperature differences; both differed significantly from baseline
Original publication
Efficacy of the intertransverse process block: single or multiple injection? A randomized, non-inferiority, blinded, cross-over trial in healthy volunteers. Reg Anesth Pain Med. Published 3 November 2023. doi:10.
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