No quadriceps muscle weakness following anterior quadratus lumborum block compared with placebo: a randomized, non-inferiority, blinded, volunteer trial
Primary result · Change in maximal quadriceps muscle strengthResult — go to the resultDifference 15.88 N 95% CI −12.19 to +43.94Authors' conclusion
In this randomized controlled trial including healthy volunteers a unilateral anterior quadratus lumborum block does not cause statistical or clinical significant motor block of the quadriceps muscle compared with placebo.
Study context
- Population
- Healthy volunteers
- Participants
- 20 healthy volunteers
- Comparison
- Unilateral anterior QL block vs placebo block on the contralateral side
- Primary endpoint
- Change in maximal quadriceps muscle strength vs placebo
- Follow-up
- Baseline to 60 min postblock
Methodological detailsnon-inferiority, triple-blind, volunteer trial, within-subject (active block one side, placebo contralateral)
- Non-inferiority
- Triple-blind
- Volunteer trial
- Within-subject (active block one side, placebo contralateral)
Primary result
Change in maximal quadriceps muscle strength · 60 min postblock
Difference
15.88 N
95% CI −12.19 to +43.94
pnon-inf=0.003
Active block vs Placebo block
difference 15.88 N (95% CI −12.19 to +43.94); pnon-inf=0.003
As reported in the abstract
Secondary outcomes
Change in Timed-Up and Go test · 60 min postblock
- Timed-Up and Go test performed significantly faster 60 min postblock
- −0.23 s (95% CI −0.38 to −0.08, p=0.005)
Change in MAP · baseline to 30 min postblock
- Mean change in MAP from baseline to 30 min postblock
- 4.25 mm Hg (95% CI 0.24 to 8.26, p=0.04)
Dermatomal affection
- Affection primarily of the lower abdomen (Th10-L1) with the active block
Original publication
No quadriceps muscle weakness following anterior quadratus lumborum block compared with placebo: a randomized, non-inferiority, blinded, volunteer trial. Reg Anesth Pain Med. Published 16 May 2024. doi:10.
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