Cardiothoracic & vascular anesthesia
Efficacy of perioperative prophylactic administration of corticosteroids in pediatric cardiac surgeries using cardiopulmonary bypass: a systematic review with meta-analysis
Pooled resultResult — go to the resultRelative risk 0.69 95% CI 0.40–1.17Authors' conclusion
In conclusion, perioperative prophylactic corticosteroid administration in pediatric cardiac surgeries using cardiopulmonary bypass did not decrease postoperative in-hospital mortality compared with placebo.
Study context
- Population
- Pediatric cardiac surgeries using CPB11 studies
- Comparison
- Perioperative prophylactic corticosteroids vs placebo
- Outcome
- Postoperative in-hospital mortality
Methodological detailstrial sequential analysis
- Trial sequential analysis
Pooled result
As reported in the abstract
Relative risk
0.69
95% CI 0.40–1.17
Corticosteroids vs Placebo
RR 0.69 (95% CI 0.40–1.17)
Further pooled results
| Outcome | Mean difference (h) (95% CI) | |
|---|---|---|
| Duration of mechanical ventilation | −5.54 (−9.75 - −1.34) | |
| −10−505Difference, h (linear scale) |
| Outcome | RR (95% CI) | |
|---|---|---|
| Low cardiac output syndrome | 0.75 (0.59–0.96) | |
| 0.512Relative risk (log scale) |
| Outcome | Mean difference (days) (95% CI) | |
|---|---|---|
| ICU LOS | −0.28 (−0.74 - 0.17) | |
| Hospital LOS | −0.59 (−1.31 - 0.14) | |
| −2−101Difference, days (linear scale) |
Postoperative in-hospital mortality, by type of corticosteroid and in neonates (subgroup)
- Corticosteroids did not decrease postoperative in-hospital mortality
Original publication
Efficacy of perioperative prophylactic administration of corticosteroids in pediatric cardiac surgeries using cardiopulmonary bypass: a systematic review with meta-analysis. Anaesth Crit Care Pain Med. Published 25 July 2023. doi:10.
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