Cardiothoracic & vascular anesthesia
Prophylactic Dexmedetomidine Reduces Junctional Ectopic Tachycardia and Facilitates Postoperative Recovery in Pediatric Cardiac Surgery: A Systematic Review and Meta‐Analysis of Prospective Trials
Pooled result · Postoperative JET incidenceResult — go to the resultOdds ratio 0.37 95% CI 0.23–0.58Authors' conclusion
In prospective pediatric cardiac surgery trials, prophylactic dexmedetomidine was associated with reduced postoperative JET, supported by moderate-certainty evidence.
Study context
- Population
- Children undergoing congenital heart surgery
- Participants
- 639 children · 5 prospective trials
- Comparison
- Prophylactic dexmedetomidine vs control
- Outcome
- Postoperative Junctional Ectopic Tachycardia (JET) incidence
Methodological detailsrandomized and quasi-randomized trials, random-effects models, GRADE
- Randomized and quasi-randomized trials
- Random-effects models
- GRADE
Pooled result
As reported in the abstract
Odds ratio
0.37
95% CI 0.23–0.58
P < 0.0001
Dexmedetomidine vs Control
OR 0.37 (95% CI 0.23–0.58); P < 0.0001
Further pooled results
| Outcome | MD (h) |
|---|---|
| Mechanical ventilation durationDexmedetomidine vs Control · substantial clinical heterogeneity · low to very-low certainty of evidence | −4.80 |
| ICU LOSDexmedetomidine vs Control · substantial clinical heterogeneity · low to very-low certainty of evidence | −19.83 |
Vasoactive-Inotropic Score (VIS)
- Significant reduction in VIS only in the sensitivity analysis; hypothesis-generating
Mortality and hypotension
- No significant differences
Original publication
Prophylactic Dexmedetomidine Reduces Junctional Ectopic Tachycardia and Facilitates Postoperative Recovery in Pediatric Cardiac Surgery: A Systematic Review and Meta‐Analysis of Prospective Trials. Paediatr Anaesth. Published 8 April 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →