Cardiothoracic & vascular anesthesia
Co-administration of dexmedetomidine with total intravenous anaesthesia in carotid endarterectomy reduces requirements for propofol and improves haemodynamic stability: A single-centre, prospective, randomised controlled trial
Authors' conclusion
Co-administration of dexmedetomidine to total intravenous anaesthesia for carotid endarterectomy decreased the effect-site concentrations of propofol required for burst suppression by 33%.
Study context
- Population
- Patients undergoing carotid endarterectomy with EEG-guided TIVA, University Hospital of Berne, Switzerland, October 2018 to September 2024
- Participants
- 23 vs 22
- Comparison
- Dexmedetomidine added to TIVA vs TIVA alone
- Controln = 23reference
- Dexmedetomidinen = 22
- Primary endpoint
- Effect-site concentration of propofol required for burst suppression
Methodological detailssingle-centre
- Single-centre
Primary result
As reported in the abstract
Propofol effect-site concentration for burst suppression
P < 0.001
Secondary outcomes
Total norepinephrine requirement
P = 0.015
Intraoperative neurophysiological monitoring
- Dexmedetomidine did not affect intraoperative neurophysiological monitoring
Original publication
Co-administration of dexmedetomidine with total intravenous anaesthesia in carotid endarterectomy reduces requirements for propofol and improves haemodynamic stability: A single-centre, prospective, randomised controlled trial. Eur J Anaesthesiol. Published 11 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →