Efficacy and safety of Ciprofol compared with Propofol during general anesthesia induction: A systematic review and meta-analysis of randomized controlled trials (RCT)
Pooled result · Anesthesia success rateResult — go to the resultRR for anesthesia success 1.00 95% CI 0.99–1.01Authors' conclusion
In conclusion, Ciprofol is not inferior to Propofol in terms of its effectiveness in general anesthesia. Ciprofol emerges as a valuable alternative sedative with fewer side effects, especially reduced injection pain, when compared to Propofol.
Study context
- Population
- Patients undergoing GA induction
- Participants
- 1,998 patients · 13 Randomized Controlled Trials (RCTs)
- Comparison
- Ciprofol vs propofol for GA induction
- Outcome
- Anesthesia success rate (efficacy)
Pooled result
Anesthesia success rate
RR for anesthesia success
1.00
95% CI 0.99–1.01
P = 0.43
Ciprofol vs Propofol
RR for anesthesia success 1.00 (95% CI 0.99–1.01); P = 0.43
As reported in the abstract
Safety
| Outcome | RR (95% CI) | P value | |
|---|---|---|---|
| Pain upon injectionI^2 = 43% | 0.15 (0.10–0.23) | P < 0.0000001 | |
| HypotensionI^2 = 48% | 0.82 (0.68–0.98) | P = 0.03 | |
| 0.10.31310Relative risk (log scale) |
Postoperative hypertension, bradycardia, tachycardia
- No statistically significant differences
Original publication
Efficacy and safety of Ciprofol compared with Propofol during general anesthesia induction: A systematic review and meta-analysis of randomized controlled trials (RCT). J Clin Anesth. Published 26 February 2024. doi:10.
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