Hemodynamics, fluids & transfusion
Efficacy and Safety of Hypertonic Saline Solution With Loop Diuretics in Patients With Acute Heart Failure: A Protocol for Systematic Review and Meta‐Analysis
Study context
- Population
- Patients hospitalised with acute HF
- Planned comparison
- Hypertonic saline solution (HSS) added to IV loop diuretics vs placebo or another control
- Primary endpoint
- All-cause mortality
Methodological detailstrial sequential analysis, Cochrane risk of bias tool version 2, grading of recommendations, assessment, development and evaluations (GRADE) and confidence in network meta-analysis (CINEMA) certainty assessment, Search planned to begin in May 2025
- Trial sequential analysis
- Cochrane risk of bias tool version 2
- GRADE and CINEMA certainty assessment
- Search planned to begin in May 2025
No results yet. This paper sets out the design of a trial; its results are to come.
Original publication
Efficacy and Safety of Hypertonic Saline Solution With Loop Diuretics in Patients With Acute Heart Failure: A Protocol for Systematic Review and Meta‐Analysis. Acta Anaesthesiol Scand. Published 19 June 2025. doi:10.
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