Efficacy and safety of topical lignocaine anesthesia in improving patient satisfaction after endobronchial ultrasound–guided transbronchial needle aspiration under general anesthesia: A randomized controlled trial
Authors' conclusion
During EBUS-TBNA under general anesthesia, 1% lignocaine for topical anesthesia significantly decreased the incidence of postoperative coughing and increased patient satisfaction.
Study context
- Population
- Patients undergoing elective EBUS-TBNA under GArandomised
- Participants
- 196 patients
- Comparison
- Topical anaesthesia with 1% lignocaine vs saline
- Tn = 91
- Cn = 94reference
- Primary endpoint
- Coughing frequency immediately after laryngeal mask removal
- Follow-up
- Immediately after laryngeal mask removal
Methodological detailsdouble-blind, single-centre, prospective
- Double-blind
- Single-centre
- Prospective
Primary result
As reported in the abstract
Cough rate and VAS score · immediately after mask removal
- Lignocaine significantly reduced cough rate and VAS score
- T vs C: P < 0.001
- T vs C: < 0.001
Secondary outcomes
| Outcome | P value |
|---|---|
| Cough rate and VAS score · 10 min after mask removalT vs C · cough rate | P < 0.001 |
| Cough rate and VAS score · 10 min after mask removalT vs C · VAS score | < 0.001 |
| Cough rate and VAS score · 30 min after mask removalT vs C · cough rate | P = 0.005 |
| Cough rate and VAS score · 30 min after mask removalT vs C · VAS score | 0.001 |
| Cough rate and VAS score · 2 h post-procedureT vs C · cough rate | P = 0.003 |
| Cough rate and VAS score · 2 h post-procedureT vs C · VAS score | 0.006 |
| QoR-15 · 24 h after the procedure | P < 0.001 |
Cough rate and VAS score · 10 min after mask removal
- Significantly reduced with lignocaine
Cough rate and VAS score · 30 min after mask removal
- Significantly reduced with lignocaine
Cough rate and VAS score · 2 h post-procedure
- Significantly reduced with lignocaine
QoR-15 · 24 h after the procedure
- Higher in T than C
Safety
- No significant effect on vital signs
Original publication
Efficacy and safety of topical lignocaine anesthesia in improving patient satisfaction after endobronchial ultrasound–guided transbronchial needle aspiration under general anesthesia: A randomized controlled trial. Anaesth Crit Care Pain Med. Published 21 February 2025. doi:10.
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