Electroencephalographic Features of Elderly Patients during Anesthesia Induction with Remimazolam: A Substudy of a Randomized Controlled Trial
Authors' conclusion
Both regimens showed a greater decrease in feedback connectivity compared to a decrease in feedforward connectivity after loss of consciousness, leading to a disruption of asymmetry between the frontoparietal connectivity.
Study context
- Population
- Elderly surgical patients undergoing anaesthesia induction
- Participants
- 26 vs 26
- Comparison
- Remimazolam vs propofol for anaesthesia induction
- Remimazolamn = 26
- Propofoln = 26reference
Methodological detailspatient-blinded
- Patient-blinded
Primary result
As reported in the abstract
Alpha-band feedback connectivity (normalized symbolic transfer entropy) after LOC vs baseline
Remimazolam vs Propofol: 95% CI −0.073 to −0.044; P < 0.001 · Propofol: 95% CI −0.068 to −0.042; P < 0.001
Further findings
Power of each frequency over time
- No significant differences between the two hypnotic agents (minimum q value)
- 0.4235
Original publication
Electroencephalographic Features of Elderly Patients during Anesthesia Induction with Remimazolam: A Substudy of a Randomized Controlled Trial. Anesthesiology. Published 9 January 2024. doi:10.
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