Elevated antibiotic resistance gene abundance of ICU healthcare workers, a multicentre, cross-sectional study
Main finding · Total ARG abundanceResult — go to the resultFold change 1.22 95% CI 1.12–1.34Authors' conclusion
In this prospective, multicenter study, we found that ICU healthcare workers exhibit significantly higher gut ARGs abundance compared to healthy controls.
Study context
- Population
- ICU healthcare workers and healthy controls, 8 medical centres in China, January–February 2024290 analysed
- Participants
- 303 workers
- Exposure
- ICU healthcare workers vs healthy controls
- ICU healthcare workersn = 191
- Healthy controlsn = 99reference
- Outcome
- Total antibiotic resistance gene (ARG) abundance in fecal metagenomic sequencing
Methodological detailsprospective, multicentre
- Prospective
- Multicentre
Main finding
Total ARG abundance
Fold change
1.22
95% CI 1.12–1.34
P < 0.001
ICU healthcare workers vs Healthy controls
fold change 1.22 (95% CI 1.12–1.34); P < 0.001
As reported in the abstract
Observational data: associations, not effects.
Further findings
ARG β-diversity
- Differed significantly between the two groups
- P = 0.001
Duration of ICU occupational exposure vs ARG abundance
- No significant linear or nonlinear relationship (p for overall)
- 0.96
- p for nonlinear
- 0.84
Original publication
Elevated antibiotic resistance gene abundance of ICU healthcare workers, a multicentre, cross-sectional study. Crit Care. Published 30 April 2025. doi:10.
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