Pediatric anesthesia & critical care
Elevated Renal-Resistive Index as an Indicator of Acute Kidney Injury Associated With Neonatal Extracorporeal Membrane Oxygenation
Authors' conclusion
The elevation of the RRI demonstrated a strong correlation with the onset of neonatal ECMO-related AKI
Study context
- Population
- Neonates treated with extracorporeal membrane oxygenation (ECMO) at a teaching hospital, June 2021–December 2022
- Participants
- 16 neonates
- Exposure
- Renal-resistive index (RRI) during ECMO in neonates with vs without acute kidney injury (AKI)
- Outcome
- RRI during ECMO therapy in patients with vs without AKI
Methodological detailssingle-centre, teaching hospital
- Single-centre
- Teaching hospital
Main finding
As reported in the abstract
RRI during ECMO
- RRI during ECMO significantly elevated in patients with AKI vs without AKI
Observational data: associations, not effects.
Secondary outcomes
Association of RRI >0.797 with AKI (logistic regression)
| Estimate | P value | ||
|---|---|---|---|
| RRI >0.797Univariate | OR 1.433 (95% CI 1.192–1.873) | P < 0.05 | |
| RRI >0.797Adjusted for serum cystatin C and SOFA score | aOR 1.352 (95% CI 1.108–1.612) | P < 0.05 | |
| 0.512Ratio (log scale) |
| Outcome | Values |
|---|---|
| Diagnostic accuracy of RRI >0.797 for AKI (ROC analysis) | RRI >0.797 optimal cutoff 0.797 · AUC 0.855 (95% CI, 0.664-1, p = 0.027) · sensitivity 72.7% · specificity 80% |
Original publication
Elevated Renal-Resistive Index as an Indicator of Acute Kidney Injury Associated With Neonatal Extracorporeal Membrane Oxygenation. J Cardiothorac Vasc Anesth. Published 5 December 2023. doi:10.
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