Respiratory failure & ventilation
End-tidal carbon dioxide during spontaneous breathing trial to predict extubation failure: A prospective observational study
Authors' conclusion
Our study suggests that recording EtCO2 during successful SBT appears to have limited predictive value for EF.
Study context
- Population
- Patients undergoing planned extubation after a successful 1-h low pressure support spontaneous breathing test (SBT) (excluding tracheostomy and T-tube SBT)
- Participants
- 189 patients
- Exposure
- EtCO2 during SBT in extubation failure (EF) vs successful extubation
- Outcome
- Clinical utility of EtCO2 to predict EF
Main finding
As reported in the abstract
EtCO2 before SBT · before SBT
P = 0.02
Observational data: associations, not effects.
Further findings
EtCO2 at 5 min of SBT · 5 minutes
P = 0.06
EtCO2 at end of SBT
P = 0.09
Independent predictors of EF (multivariable analysis)
- Acute respiratory failure as cause of intubation and ineffective cough independently associated with EF
Original publication
End-tidal carbon dioxide during spontaneous breathing trial to predict extubation failure: A prospective observational study. J Crit Care. Published 19 July 2024. doi:10.
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