Respiratory failure & ventilation
Epidemiology of acute hypoxaemic respiratory failure in Australian and New Zealand intensive care units during 2005–2022. A binational, registry-based study
Authors' conclusion
The healthcare burden due to AHRF may be larger than expected, and mortality rates remain high in severe AHRF. Although mortality has decreased over time, this may reflect improvements in ICU care in general, rather than specifically in AHRF.
Study context
- Population
- Adults admitted to an Australian or New Zealand intensive care unit (ICU) with an arterial blood gas within the first 24 h, 2005–2022826,106 (52.9%) with acute hypoxaemic respiratory failure (AHRF)
- Participants
- 1,560,221 adults
- Exposure
- AHRF severity by PaO2/FiO2 vs no AHRF
- Outcome
- Adjusted in-hospital mortality, categorised by PaO2/FiO2 (mild: 200-300, moderate: 100-200, severe < 100, and non-linearly)
Methodological detailsbinational
- Binational
Main finding
As reported in the abstract
In-hospital mortality
- Adjusted in-hospital mortality progressively increased as PaO2/FiO2 decreased, particularly below an inflection point at PaO2/FiO2 200
- 200
Observational data: associations, not effects.
Further findings
| Outcome | Mild | Moderate | Severe |
|---|---|---|---|
| AHRF severity distribution among AHRF patients | 51.4% | 39.3% | 9.3% |
Adjusted in-hospital mortality over time, all patients
- Decreased from 2005 to 2022
- 13.3% to 8.2%
- Trend similar in patients with and without AHRF
Original publication
Epidemiology of acute hypoxaemic respiratory failure in Australian and New Zealand intensive care units during 2005–2022. A binational, registry-based study. Intensive Care Med. Published 2 September 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →