Epidemiology of Septic Shock Associated Acute Kidney Injury: A National Retrospective Cohort Study
Authors' conclusion
Among hospitalized patients with septic shock, most patients have AKI, and stage 3 AKI is associated with the highest risk of mortality.
Study context
- Population
- Adults with septic shock on hospital admission, 220 US community and teaching hospitalsfinal cohort
- Participants
- 21,803 adults
- Exposure
- Acute kidney injury (AKI) stage 1, 2 or 3 vs no AKI
- Outcome
- Frequency of AKI, MAKE-30 and RRT; association of AKI stage with in-hospital mortality
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
AKI frequency and mortality by AKI stage
Each group vs no AKIOdds ratio (95% CI)P value
Stage 1
1.12(0.97–1.29)
P = 0.109Stage 2
1.25(1.09–1.43)
P = 0.001Stage 3
1.66(1.46–1.89)
P < 0.001- AKI during hospital admission
- 92.8%
- Renal replacement therapy (RRT)
- 6.4%
- MAKE-30
- 42.0%
- Died
- 30.9%
Observational data: associations, not effects.
Original publication
Epidemiology of Septic Shock Associated Acute Kidney Injury: A National Retrospective Cohort Study. Crit Care Med. Published 13 June 2025. doi:10.
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