Respiratory failure & ventilation
Epidemiology of the acute respiratory distress syndrome and the prognostic validity of SpO2:FiO2 under the expanded Global definition
Authors' conclusion
Our work establishes an increased incidence and modestly decreased time to diagnosis of ARDS under the Global definition and supports the prognostic validity of SFR.
Study context
- Population
- Critically ill patients with sepsis
- Participants
- 950 patients
- Exposure
- 2023 Global vs 2012 Berlin acute respiratory distress syndrome (ARDS) definitions
- Globaln = 466
- Berlinn = 427reference
- Outcome
- Incidence and outcomes of ARDS under Berlin vs Global definitions; relationship of SFR-derived severity categories with mortality
Main finding
As reported in the abstract
ARDS incidence · 6-day follow-up
Observational data: associations, not effects.
Further findings
| Outcome | Median difference (h earlier) |
|---|---|
| Time to ARDS qualification | 3.0 |
Mortality
- Comparable between Global and Berlin definitions at onset; substantially lower for patients who never met the Berlin definition
Prognostic validity of SFR · 30 days
- SFR predictive of 30-day mortality; moderate correlation with PaO2:FiO2 ratio
Original publication
Epidemiology of the acute respiratory distress syndrome and the prognostic validity of SpO2:FiO2 under the expanded Global definition. Crit Care. Published 8 May 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →