Evaluating the effects of continuous veno-venous hemodiafiltration on O2 and CO2 removal and energy expenditure measurement using indirect calorimetry
Authors' conclusion
CVVHDF may significantly alter QCO₂ levels without affecting QO₂, influencing the REE and RQ results measured by IC. However, the impact on REE is not clinically significant, and the REE value obtained via IC is closer to the true REE than that estimated using the Harris-Benedict equation.
Study context
- Population
- Patients with sepsis undergoing continuous veno-venous hemodiafiltration (CVVHDF)
- Exposure
- Downstream vs Upstream
- Outcome
- Effects of CVVHDF on O₂ and CO₂ removal (QCO₂, QO₂ before and after the filter) and accuracy of REE measurement using IC
Methodological detailssingle-center
- Single-center
Main finding
As reported in the abstract
QCO₂ across the filter
P < 0.0001
Observational data: associations, not effects.
Further findings
| Outcome | Values | P value |
|---|---|---|
| REE: true vs measured (IC) vs estimated (Harris-Benedict)True REE vs Measured REE · significantly different | True REE mean 1774.28 (SD 438.20) kcal/day · Measured REE mean 1758.59 (SD 434.06) kcal/day · Estimated REE mean 1619.36 (SD 295.46) kcal/day | P = 0.0029 |
| REE: true vs measured (IC) vs estimated (Harris-Benedict)True REE vs Estimated REE · significantly different | P = 0.0475 | |
| RQ: measured vs trueSignificant difference | Measured RQ mean 0.693 (SD 0.118) · True RQ mean 0.731 (SD 0.121) | P < 0.0001 |
Original publication
Evaluating the effects of continuous veno-venous hemodiafiltration on O2 and CO2 removal and energy expenditure measurement using indirect calorimetry. Ann Intensive Care. Published 11 January 2025. doi:10.
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