Perioperative medicine & outcomes
Evaluating the Impact of Leukotriene Receptor Antagonists on Postoperative Acute Kidney Injury: A Retrospective Study
Main findingResult — go to the resultRelative risk 0.79 95% CI 0.60–1.06Authors' conclusion
Perioperative use of leukotriene receptor antagonists was not significantly associated with a lower risk of postoperative AKI following oncologic surgery.
Study context
- Population
- Adults undergoing oncological surgery, April 1, 2016 to September 30, 2025
- Participants
- 45,751 adults
- Exposure
- Perioperative leukotriene receptor antagonist use vs no use
- Leukotriene receptor antagonistn = 555
- Outcome
- Acute kidney injury (AKI) (Kidney Disease Improving Global Outcomes (KDIGO) definition)
- Follow-up
- Within 7 days of surgery
Methodological detailssingle-centre, propensity score-overlap weighting
- Single-centre
- Propensity score-overlap weighting
Main finding
As reported in the abstract
Relative risk
0.79
95% CI 0.60–1.06
P = 0.12
Leukotriene receptor antagonist vs Non-users
RR 0.79 (95% CI 0.60–1.06); P = 0.12
Observational data: associations, not effects.
Secondary outcomes
| Outcome | Leukotriene receptor antagonist | Non-users | Adjusted risk difference (95% CI) | P value | |
|---|---|---|---|---|---|
| Surgical reintervention · 7 daysAdjusted risks | 38.37% | 33.92% | 4.45% (0.31–8.59) | P = 0.035 | |
| −50510Difference (linear scale) |
Safety
| Outcome | Leukotriene receptor antagonist | Non-users | Adjusted risk difference (95% CI) | P value | |
|---|---|---|---|---|---|
| Surgical reintervention · 7 daysAdjusted risks | 38.37% | 33.92% | 4.45% (0.31–8.59) | P = 0.035 | |
| −50510Difference (linear scale) |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Evaluating the Impact of Leukotriene Receptor Antagonists on Postoperative Acute Kidney Injury: A Retrospective Study. Anesth Analg. Published 23 September 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →