Cardiothoracic & vascular anesthesia
Evaluation of Activated Clotting Times With a Heparin Reversal Protocol Designed to Conserve Protamine During Drug Shortages: A Retrospective, Cohort Study
Main finding · First activated clotting time after initial protamine administrationResult — go to the resultDifference 1.47 s 99% CI −1.47 to 4.94Authors' conclusion
Conservation measures regarding critical medications and supplies during times of shortages can maintain access to important services within a community.
Study context
- Population
- Cardiac surgical patients >18 years old who received >30,000 U of heparin, in-patient hospital setting
- Participants
- 801 patients
- Exposure
- Low Dose vs Conventional Dose
- Outcome
- Post-reversal activated clotting times
Main finding
As reported in the abstract
First activated clotting time after initial protamine administration
Difference
1.47 s
99% CI −1.47 to 4.94
P = 0.16
By group
Low Dose vs Conventional Dose
difference 1.47 s (99% CI −1.47 to 4.94); P = 0.16
Observational data: associations, not effects.
Secondary outcomes
| Outcome | Difference (mg) (99% CI) | P value | |
|---|---|---|---|
| Total protamine administered | −100.5 (−110.0 to −91.0) | P < 0.0001 | |
| −150−100−50050Difference, mg (linear scale) |
| Outcome | Difference (99% CI) | P value | |
|---|---|---|---|
| Number of protamine vials used per case (250 mg vials) | −0.69 (−0.75 to −0.63) | P < 0.0001 | |
| Vials used per case (50 mg vials) | −2.16 (−2.36 to −1.97) | P < 0.0001 | |
| −3−2−101Difference (linear scale) |
Initial protamine dose
- Number of protamine vials used per case (250 mg vials): mean vials P: p < 0.0001
- Initial protamine dose: p < 0.0001
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Evaluation of Activated Clotting Times With a Heparin Reversal Protocol Designed to Conserve Protamine During Drug Shortages: A Retrospective, Cohort Study. J Cardiothorac Vasc Anesth. Published 18 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →