Evaluation of whole blood thiamine pyrophosphate concentrations in critically ill patients receiving chronic diuretic therapy prior to admission to Turkish intensive care units: A pragmatic, multicenter, prospective study
Authors' conclusion
Our results show that 18% of these critically ill patients exhibited low whole blood TPP concentrations on ICU admission and 26% had low levels during the initial 10 ICU days, respectively.
Study context
- Population
- Critically ill patients receiving chronic diuretic treatment before ICU admission, 15 Turkish medical ICUs
- Participants
- 221 patients
- Outcome
- Serial whole blood thiamine pyrophosphate (TPP) concentrations (HPLC) and correlation with serum phosphorus
- Follow-up
- Baseline and days 2, 5 and 10 after ICU admission
Methodological detailspragmatic, multicentre
- Pragmatic
- Multicentre
Main finding
As reported in the abstract
Low whole blood TPP concentrations
Low TPP on ICU admission
18%
Low TPP at some point during the 10-day study period
26%
Observational data: associations, not effects.
Further findings
Hypophosphatemia · 10-day observation period
- Hypophosphatemia at some point during the 10-day period
- 30%
Correlation of TPP with serum phosphorus · each time point
- TPP significantly and positively correlated with serum phosphorus at each time point
- P < 0.05 for all
Original publication
Evaluation of whole blood thiamine pyrophosphate concentrations in critically ill patients receiving chronic diuretic therapy prior to admission to Turkish intensive care units: A pragmatic, multicenter, prospective study. J Crit Care. Published 13 May 2023. doi:10.
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