Hemodynamics, fluids & transfusion
Frailty and long-term mortality in cardiogenic shock: a binational multicentre cohort study
Main finding · DeathResult — go to the resultAdjusted hazard ratio 2.27 95% CI 2.05–2.51Authors' conclusion
Frailty is associated with mortality beyond ICU discharge in cardiogenic shock in a non-linear, stepwise fashion.
Study context
- Population
- Adults (≥ 16 years) admitted to ICU with cardiogenic shock and a documented Clinical Frailty Scale (CFS), ANZICS Adult Patient Database, 188 intensive care units (ICUs), 2017–2023
- Participants
- 71,359 adults · 188 ICUs
- Exposure
- Frailty vs no frailty
- Frailtyn = 11,087
- Outcome
- Death (adjusted Cox proportional hazards model)
- Follow-up
- Up to four years
Methodological detailsmulticentre, binational, registry
- Multicentre
- Binational
- Registry
Main finding
Death
Adjusted hazard ratio
2.27
95% CI 2.05–2.51
Frailty vs No frailty
aHR 2.27 (95% CI 2.05–2.51)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | |
|---|---|---|
| Death, time-varying analysis (peak hazard) · approximately six months post-ICU admission | HR 3.71 (95% CI 3.29–4.18) | |
| Death, landmark survival analysis at ICU discharge | aHR 3.13 (95% CI 2.82–3.48) | |
| 0.20.5125Ratio (log scale) |
Death, subgroups (aetiology, sex)
- Frailty more strongly associated with death in ischaemic than non-ischaemic cardiogenic shock, and in males more than females
Original publication
Frailty and long-term mortality in cardiogenic shock: a binational multicentre cohort study. Crit Care. Published 25 March 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →