Pediatric anesthesia & critical care
Global anaesthesia-related cardiac arrest rates in children: a systematic review and meta-analysis
Authors' conclusion
The high and alarming anaesthesia-related cardiac arrest rates among children younger than 1 yr of age in high-HDI and low-HDI countries, respectively, reflect an ongoing challenge for anaesthesiologists.
Study context
- Population
- Children undergoing anaesthesia; studies reporting 24-h postoperative anaesthesia-related cardiac arrest rates
- Participants
- 5,493,489 children · 38 studies
- Comparison
- Low-HDI vs high-HDI countries; pre-2001 vs 2001-22
- Outcome
- Anaesthesia-related cardiac arrest rate (ARCAR) per 10,000 anaesthetic procedures
- Follow-up
- 24-h postoperative
Methodological detailsmeta-regression, Electronic databases searched up to July 2022
- Meta-regression
- Electronic databases searched up to July 2022
Pooled result
As reported in the abstract
ARCAR per 10,000 anaesthetic procedures
P < 0.0001
- Anaesthesia-related cardiac arrest rate (ARCARs) inversely correlated with country Human Development Index (HDI)
- P < 0.0001
- ARCARs not correlated with time
- P = 0.82
- No change between periods in high-HDI countries
- P = 0.71
- No change between periods in low-HDI countries
- P = 0.62
Further pooled results
| Outcome | <1 yr | ≥1 yr | OR (95% CI) | P value | |
|---|---|---|---|---|---|
| ARCAR, age <1 yr vs ≥1 yr (subgroup), high-HDI countries · 2001-22 | 10.69 per 10,000 anaesthetic procedures | 1.48 per 10,000 anaesthetic procedures | 8.03 (5.96–10.81) | P < 0.0001 | |
| ARCAR, age <1 yr vs ≥1 yr (subgroup), low-HDI countries · 2001-22 | 36.02 per 10,000 anaesthetic procedures | 2.86 per 10,000 anaesthetic procedures | 7.32 (3.48–15.39) | P < 0.0001 | |
| 0.050.21520Odds ratio (log scale) |
Original publication
Global anaesthesia-related cardiac arrest rates in children: a systematic review and meta-analysis. Br J Anaesth. Published 22 September 2023. doi:10.
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