Glucagon-like peptide-1 receptor agonists and gastric emptying time: a systematic review and meta-analysis of prospective studies
Authors' conclusion
In this systematic review and meta-analysis, we found that GLP-1 RAs significantly prolonged gastric emptying T½ by a mean of 74 min
Study context
- Population
- Adults aged ≥ 18 yr taking a GLP-1 RA for diabetes mellitus and/or weight loss
- Participants
- 300 adults · 10 studies
- Comparison
- GLP-1 RA treatment vs no GLP-1 RA treatment
- Outcome
- Gastric emptying half-time (T½)
Methodological detailsmultilevel random effects meta-analysis, Grading of Recommendations Assessment, Development and Evaluation (GRADE) certainty assessment
- Multilevel random effects meta-analysis
- GRADE certainty assessment
Pooled result
As reported in the abstract
Gastric emptying T½
GLP-1 RA vs No GLP-1 RASMD (95% CI)P value
Large effect size
2.38(1.05–3.71)
P < 0.001- Gastric emptying T½
- mean prolongation 74 min (95% CI 46–101)
Further pooled results
| Outcome | SMD (95% CI) | |
|---|---|---|
| Gastric emptying T½, short-acting GLP-1 RAs (subgroup)GLP-1 RA vs No GLP-1 RA · trend towards a more pronounced effect | 3.86 (2.37–5.35) | |
| Gastric emptying T½, early treatment phases (< 10 weeks) (subgroup)GLP-1 RA vs No GLP-1 RA · trend towards a more pronounced effect | 2.72 (1.15–4.35) | |
| −50510Difference (linear scale) |
| Outcome | Estimate |
|---|---|
| Gastric emptying T½, short-acting GLP-1 RAs (subgroup)GLP-1 RA vs No GLP-1 RA · trend towards a more pronounced effect | prolongation 116 min (95% CI 71–161) |
| Gastric emptying T½, early treatment phases (< 10 weeks) (subgroup)GLP-1 RA vs No GLP-1 RA · trend towards a more pronounced effect | mean prolongation 82 min (95% CI 35–131) |
Original publication
Glucagon-like peptide-1 receptor agonists and gastric emptying time: a systematic review and meta-analysis of prospective studies. Can J Anaesth. Published 5 May 2026. doi:10.
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