Respiratory failure & ventilation
Handgrip strength association with weaning outcome in mechanically ventilated intensive care unit (ICU) patients: a systematic review and meta-analysis
Pooled result · HGS, extubation failure vs successResult — go to the resultMean difference - 3.62 kg 95% CI - 7.92 to 0.62Authors' conclusion
Maximal HGS does not appear to significantly differentiate extubation success from failure
Study context
- Population
- Mechanically ventilated adult ICU patients with maximal handgrip strength (HGS) measured before extubation
- Participants
- 707 participants · 7 studies
- Comparison
- Maximal HGS before extubation: poor vs good weaning outcome
- Outcome
- Association of HGS with weaning outcomes:
- Extubation failure
- Spontaneous breathing trial (SBT) failure
- Weaning classification
Methodological detailshierarchical summary ROC model, QUIPS risk of bias assessment
- Hierarchical summary ROC model
- QUIPS risk of bias assessment
Pooled result
HGS, extubation failure vs success
Mean difference
- 3.62 kg
95% CI - 7.92 to 0.62
As reported in the abstract
Further pooled results
| Outcome | Values | Mean difference (kg) (95% CI) |
|---|---|---|
| HGS, SBT failure vs successSignificantly lower HGS | −3.00 (- 4.64 to - 1.36) | |
| HGS, non-simple vs simple weaningSignificantly lower HGS | −3.94 (- 5.31 to - 2.58) | |
| Diagnostic accuracy of HGS for extubation failure or non-simple weaning | HGS pooled sensitivity 72% · pooled specificity 60% · NPV (10% to 20% pre-test probability) 90% to 95% |
Original publication
Handgrip strength association with weaning outcome in mechanically ventilated ICU patients: a systematic review and meta-analysis. Crit Care. Published 7 November 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →