Cardiothoracic & vascular anesthesia
Hemodynamic and Perioperative Effects of Remimazolam Versus Propofol in Adult Cardiac Surgery: A Grade-Assessed Systematic Review and Meta-Analysis
Pooled result · Intraoperative hypotensive eventsResult — go to the resultRelative risk 0.50 95% CI 0.31–0.80Authors' conclusion
Remimazolam may provide superior hemodynamic stability and faster postoperative recovery compared with propofol in adult cardiac surgery without compromising anesthetic efficacy or safety.
Study context
- Population
- Adults undergoing cardiac surgery
- Participants
- 903 adults · 9 studies
- Comparison
- Remimazolam vs propofol
- Outcome
- Study-defined hypotensive events, MAP, heart rate, BIS and operative time
Methodological detailsPRISMA-compliant, random-effects, GRADE-assessed, Evidence certainty ranged from high to low, mainly due to heterogeneity and imprecision
- PRISMA-compliant
- Random-effects
- GRADE-assessed
- Evidence certainty ranged from high to low, mainly due to heterogeneity and imprecision
Pooled result
Intraoperative hypotensive events
Relative risk
0.50
95% CI 0.31–0.80
Remimazolam vs Propofol
RR 0.50 (95% CI 0.31–0.80)
As reported in the abstract
Further pooled results
Emergence (times to eye opening and extubation)
- Faster emergence with remimazolam, incl. shorter times to eye opening and extubation
Hospital LOS
- No significant difference
Safety
PONV, delirium
- No significant differences
Postoperative adverse events
- Reduced with remimazolam
Original publication
Hemodynamic and Perioperative Effects of Remimazolam Versus Propofol in Adult Cardiac Surgery: A Grade-Assessed Systematic Review and Meta-Analysis. J Cardiothorac Vasc Anesth. Published 7 July 2026. doi:10.
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