Pediatric anesthesia & critical care
Hemodynamic Impact of Mechanical Ventilation in Anesthetized Patients With Cavopulmonary Connection: A Physiologic Crossover Study
Main finding · Cardiac indexResult — go to the resultMean difference 0.6 L/min/m²Authors' conclusion
In anesthetized Glenn and Fontan patients with secured airways, spontaneous ventilation produces a superior hemodynamic profile compared with mechanical ventilation.
Study context
- Population
- Anesthetized children with cavopulmonary (Glenn or Fontan) anastomosis undergoing elective cardiac catheterizationcrossover
- Participants
- 35 children
- Exposure
- Spontaneous breathing vs mechanical ventilation under GA
- Outcome
- Cardiac index
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Mean difference
0.6 L/min/m²
P = 0.022
Observational data: associations, not effects.
Further findings
| Outcome | Mean difference (mmHg) | P value |
|---|---|---|
| Atrial pressure | 1.9 | P < 0.001 |
Pulmonary vascular resistance, transpulmonary gradient, Qp:Qs
- Did not differ significantly between ventilation methods
Original publication
Hemodynamic Impact of Mechanical Ventilation in Anesthetized Patients With Cavopulmonary Connection: A Physiologic Crossover Study. J Cardiothorac Vasc Anesth. Published 31 July 2025. doi:10.
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