Cardiothoracic & vascular anesthesia
Hemolysis Index and Cardiopulmonary Bypass Time as Predictors of Cardiac Surgery-associated Acute Kidney Injury: An Observational Cohort Study
Authors' conclusion
HI and CPB time were independently associated with CS-AKI.
Study context
- Population
- Patients admitted to the cardiothoracic intensive care unit (ICU) after cardiac surgery, Italian university tertiary care hospital, 2019–2023included in the analysis
- Participants
- 1,195 patients
- Outcome
- Association of HI and CPB time with CS-AKI (multivariable analysis)
Methodological detailsretrospective analysis of prospectively collected data, single-centre
- Retrospective analysis of prospectively collected data
- Single-centre
Main finding
As reported in the abstract
Odds ratio (95% CI)P value
HI (per 10-unit increase)
1.52(1.04–2.18)
P = 0.027CPB time (per hour)
1.32(1.08–1.63)
P < 0.001Each row per its own increment, as printed
- CS-AKI incidence
- 103 (9%)
Observational data: associations, not effects.
Further findings
Correlation of Hemolysis Index (HI) with cardiopulmonary bypass (CPB) duration
- Moderate correlation (r)
- 0.367
- P
- P < 0.001
CPB duration and HI at ICU admission
- Median CPB duration, minutes (IQR 80-140)
- 110
- Median HI at ICU admission (IQR 15-42)
- 25
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Hemolysis Index and Cardiopulmonary Bypass Time as Predictors of Cardiac Surgery-associated Acute Kidney Injury: An Observational Cohort Study. J Cardiothorac Vasc Anesth. Published 28 July 2025. doi:10.
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