Cardiothoracic & vascular anesthesia
Hemolysis Index, Carboxyhemoglobin, and Methemoglobin for the Early Identification of Patients at Risk for Cardiac Surgery–Associated Acute Kidney Injury
Authors' conclusion
Elevated HIpostoperative represents an early alert signal for the development of CS-AKI.
Study context
- Population
- Patients undergoing elective cardiac surgery at a university hospital
- Participants
- 1,090 patients
- Exposure
- CS-AKI vs No CS-AKI
- Outcome
- HIpostoperative
Methodological detailsone-year, single university hospital
- One-year
- Single university hospital
Main finding
As reported in the abstract
P < 0.001
- Area under the precision-recall curve (AUPRC) for HIpostoperative
- 37% (95% CI, 31%-42%)
- AUPRC with no discriminative power (CS-AKI prevalence)
- 21%
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | P value |
|---|---|---|
| AUPRC of HIpostoperative vs COHbpostoperative and MetHbpostoperative (patients with all 3 biomarkers)HIpostoperative vs COHbpostoperative | AUPRC difference +6.6% | P < 0.0001 |
| AUPRC of HIpostoperative vs COHbpostoperative and MetHbpostoperative (patients with all 3 biomarkers)HIpostoperative vs MetHbpostoperative | AUPRC difference +7.4% | P < 0.0001 |
| Adding HIpostoperative to a CS-AKI early recognition model (trained then validated in another sample)Model with HIpostoperative vs Model without HIpostoperative | increase in AUPRC +1.9% (95% CI 1.6%–2.1%) | P < 0.0001 |
- AUPRC of HIpostoperative vs COHbpostoperative and MetHbpostoperative (patients with all 3 biomarkers): 611 patients with measurements for all 3 biomarkers
Adding HIpostoperative to a CS-AKI early recognition model (trained then validated in another sample)
- COHbpostoperative or MetHbpostoperative did not significantly enhance model performance
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Hemolysis Index, Carboxyhemoglobin, and Methemoglobin for the Early Identification of Patients at Risk for Cardiac Surgery–Associated Acute Kidney Injury. J Cardiothorac Vasc Anesth. Published 1 October 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →