Cardiothoracic & vascular anesthesia
Mitochondrial oxygenation monitoring and acute kidney injury risk in cardiac surgery: A prospective cohort study
Authors' conclusion
This study highlighted the association between mitoPO2 and the onset of CSA-AKI. Extended durations below the mitoPO2 threshold of 25 mmHg significantly correlate with an elevated CSA-AKI risk.
Study context
- Population
- Cardiac surgery patients with an increased preoperative cardiac surgery-associated acute kidney injury (CSA-AKI) risk
- Participants
- 75 patients
- Exposure
- CSA-AKI vs No CSA-AKI
- Outcome
- Prolonged periods of intraoperative mitoPO2 < 20 mmHg in patients who developed CSA-AKI
- Follow-up
- During surgery
Methodological detailsprospective observational
- Prospective observational
Main finding
As reported in the abstract
Intraoperative time with mitoPO2 <20 mmHg
- Significantly longer intraoperative time with mitoPO2 <20 mmHg in patients who developed CSA-AKI
Observational data: associations, not effects.
Further findings
Intraoperative time with mitoPO2 <25, <30, <35 and <40 mmHg
- Significantly longer in patients who developed CSA-AKI at all thresholds
Association of time below mitoPO2 <25 mmHg with CSA-AKI risk
- <25 mmHg threshold showed the highest significant OR among thresholds; each minute below <25 mmHg increased CSA-AKI risk by
- 0.7 %
- P = 0.021
Original publication
Mitochondrial oxygenation monitoring and acute kidney injury risk in cardiac surgery: A prospective cohort study. J Clin Anesth. Published 9 December 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →