Cardiothoracic & vascular anesthesia
Herpes Simplex Virus Pneumonia in Immunocompetent Patients Undergoing Cardiac Surgery: Case Series
Authors' conclusion
HSV-1 infection emerged as a relevant finding among these cardiac surgery patients with respiratory deterioration.
Study context
- Population
- Adults without known immunodeficiency undergoing cardiac surgery with CPB, ICU43 tested for HSV
- Participants
- 818 adults
- Outcome
- HSV-1-positive BAL/BAS among patients tested for HSV (frequency)
Main finding
As reported in the abstract
Tested for HSV, of 818 cardiac surgery patients
43
Positive bronchoalveolar lavage (BAL)/bronchial aspirate (BAS) for HSV-1, of those tested
15
34.9%
Observational data: associations, not effects.
Further findings
HSV-1 viral load on BAL/BAS (quantitative PCR), HSV-1-positive patients
- Median viral load, copies/mL (IQR, 5.62 × 10⁵-5.73 × 10⁶)
- 3.21 × 10⁶
Time from surgery to diagnosis, HSV-1-positive patients
- Median days after surgery (range, 7.5-19 days)
- 12
Mechanical ventilation and ARDS, HSV-1-positive patients
- Mechanically ventilated, of 15
- 13 (86.7%)
- Met ARDS criteria
- 11 (73.3%)
Inflammatory markers, HSV-1-positive patients
- Median C-reactive protein, mg/L (IQR, 85.7-141.4)
- 108.6
- Median procalcitonin, ng/mL (IQR, 0.4-1.4)
- 1.1
ICU LOS and in-hospital mortality, HSV-1-positive patients
- Median ICU LOS, days
- 54
- In-hospital mortality
- 66.7%
- In-hospital mortality after urgent surgery
- 85.7%
- In-hospital mortality after elective surgery
- 50.0%
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →