Cardiothoracic & vascular anesthesia
Respiratory Reactivation of Herpes Simplex Virus-1 Following Cardiac Surgery in Immunocompetent Individuals
Authors' conclusion
Herpes simplex virus reactivation after cardiac surgery is not frequently reported, but mortality approaches 50%.
Study context
- Population
- Immunocompetent adults with suspected or confirmed herpes simplex virus pneumonia after cardiac surgery
- Participants
- 112 adults · 20 studies
- Outcome
- Reported HSV-1 reactivation with pneumonia after cardiac surgery: diagnosis, antiviral treatment and all-cause mortality
Methodological detailsDatabases searched from inception to June 4, 2025; studies published 1983-2025
- Databases searched from inception to June 4, 2025; studies published 1983-2025
Pooled result
As reported in the abstract
Bronchoalveolar lavage used as diagnostic tool (% of cases)
79%
Antiviral treatment (predominantly acyclovir) reported, 42 of 78 patients
53%
All-cause mortality, 14 of 30 patients
46%
Original publication
Respiratory Reactivation of Herpes Simplex Virus-1 Following Cardiac Surgery in Immunocompetent Individuals. J Cardiothorac Vasc Anesth. Published 16 September 2025. doi:10.
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