Sepsis & infection

High-density lipoprotein: a biomarker and therapeutic target in sepsis

Crit CarePublished Narrative review

Study context

Population
Sepsis

Main finding

As reported in the abstract

  • Sepsis substantially decreases high-density lipoprotein (HDL) in experimental and clinical studies
  • High HDL level associated with better sepsis-related prognosis
  • HDL protective functions: endotoxin-neutralizing, anti-bacterial, anti-inflammatory, anti-oxidative
  • Modulation of HDL as a potential therapeutic strategy in sepsis

Original publication

High-density lipoprotein: a biomarker and therapeutic target in sepsis. Crit Care. Published 27 October 2025. doi:10.1186/s13054-025-05702-2

Composed by AI from the published abstract and checked against it. How Briefs are made →

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