Relationship between high-density lipoprotein cholesterol (HDL-C) concentration and ventilator-associated pneumonia in intensive care unit (ICU) COVID-19 patients
Main finding · HDL-C on ICU admissionResult — go to the resultHazard ratio 3.91 CI 1.45–10.5Authors' conclusion
Increased HDL-C concentration on admission is strongly associated with the occurrence of VAP during severe COVID-19 infection.
Study context
- Population
- Patients with severe COVID-19 in ICU, France (LIPICOR study), October 2020 to May 2021consecutively included
- Participants
- 122 patients
- Exposure
- Ventilator-associated pneumonia (VAP) vs no VAP, by HDL-C concentration on ICU admission
- VAPn = 32
- Outcome
- Relationship between HDL-C concentration on ICU admission and occurrence of VAP
Methodological detailsconsecutive inclusion
- Consecutive inclusion
Main finding
HDL-C on ICU admission
Hazard ratio
3.91
CI 1.45–10.5
P = 0.007
By group
HDL-C at admission
HR 3.91 (CI 1.45–10.5); P = 0.007
As reported in the abstract
- VAP occurrence higher with HDL-C above 0.8 mmol/L at admission (log-rank test)
- P = 0.003
Observational data: associations, not effects.
Further findings
HDL-C concentration on ICU admission, all patients
- Median HDL-C concentration
- 0.80 [0.65, 1.03] mmol/L
VAP occurrence by HDL-C above 0.8 mmol/L at admission
- VAP occurrence higher with HDL-C above 0.8 mmol/L at admission (log-rank test)
- P = 0.003
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Relationship between high-density lipoprotein cholesterol (HDL-C) concentration and ventilator-associated pneumonia in ICU COVID-19 patients. Anaesth Crit Care Pain Med. Published 1 May 2025. doi:10.
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