Respiratory failure & ventilation
High-flow nasal oxygen therapy via a single-prong cannula interface during bronchoscopy in patients with acute respiratory failure: a two-center, open-label, randomized controlled trial
Authors' conclusion
In patients with ARF, HFNO-SPC significantly reduced the proportion of patients requiring respiratory support escalation within 24 h after FB compared with SOT.
Study context
- Population
- Patients with acute respiratory failure undergoing flexible bronchoscopyall in ITT analysis
- Participants
- 160 patients
- Comparison
- HFNO-SPC vs standard oxygen therapy (SOT)
- HFNO-SPCn = 80
- SOTn = 80reference
- Primary endpoint
- Escalation of respiratory support (invasive mechanical ventilation (IMV), noninvasive ventilation (NIV) or HFNO, or increased support parameters without mode change)
- Follow-up
- Within 24 h after FB
Methodological detailstwo-center, open-label
- Two-center
- Open-label
Primary result
As reported in the abstract
Respiratory support escalation
P = 0.006
Secondary outcomes
Hierarchical composite of escalation events
P = 0.004
Intubation · within 24 h
P = 0.022
Hierarchical composite of escalation events
- Supported the primary findings
Electrical impedance tomography (EIT): tidal impedance variation and end-expiratory lung impedance
- Smaller tidal impedance variation (TIV) reductions during flexible bronchoscopy (FB) and less pronounced ΔEELI changes during and after FB with HFNO-SPC
Original publication
High-flow nasal oxygen therapy via a single-prong cannula interface during bronchoscopy in patients with acute respiratory failure: a two-center, open-label, randomized controlled trial. Ann Intensive Care. Published 12 May 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →