Respiratory failure & ventilation
High positive end-expiratory pressure (PEEP)/low FiO2 ventilation is associated with lower mortality in COVID–19
Main findingResult — go to the resultHazard ratio 0.66 CI 0.46–0.96Authors' conclusion
High PEEP ventilation was associated with improved ICU survival in patients with COVID-ARDS.
Study context
- Population
- Invasively ventilated COVID-19 acute respiratory distress syndrome (ARDS) patients during the second wave in the Netherlands790 included (groups' n sum differs)
- Participants
- 142 vs 848
- Exposure
- High PEEP/low FiO2 vs low PEEP ventilation
- High PEEPn = 142
- Low PEEPn = 848reference
- Outcome
- ICU mortality
Methodological detailspropensity matching
- Propensity matching
Main finding
As reported in the abstract
Hazard ratio
0.66
CI 0.46–0.96
P = 0.03
Events by group
High PEEP vs Low PEEP
HR 0.66 (CI 0.46–0.96); P = 0.03
Observational data: associations, not effects.
Secondary outcomes
Hospital and 90-day mortality, duration of ventilation, LOS, kidney injury
- High PEEP linked to improved secondary outcomes
ICU mortality (propensity-matched analysis)
- Matched analysis did not change findings
Original publication
High PEEP/low FiO2 ventilation is associated with lower mortality in COVID–19. J Crit Care. Published 11 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →